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The drug has multiple and diverse effects on reproductive tissues.
The main biological properties of Danazol are binding to androgen receptors and suppression of the hypothalamic-pituitary axis, resulting in acyclic ovarian function (Dmowski et al., 1983).
Infertility, pelvic pain, and uterine bleeding are major clinical manifestations, and hysterectomies are frequently resorted to.
The rationale for inducing regression of these tumor growths with an antiprogestin was formulated soon after the demonstration of the ability of RU 486 to interrupt early pregnancy in women (Baulieu, 1989).
There was a decrease of immunostaining for PR but not for ER in leiomyomas treated with RU 486.